The paper explicitly reports no limb or digit abnormalities in mice carrying this variant. It reports other skeletal changes, but not extra digits. Richards’s account conflicts with that result.
The claim in context
The archaic human GLI3 R1537C variant and equivalent R1540C mouse model in Agata and colleagues’ 2023 study.
Richards attributes extra digits to the variant-bearing mice. This assessment checks that specific result against the paper.
Frontiers in Cell and Developmental Biology Source type: Peer-reviewedPublished · Accessed
The variant-bearing mice had no limb or digit abnormalities. The authors distinguish this result from the extra digits associated with loss of GLI3 function.
The finding concerns the tested variant and mouse model, not every GLI3 mutation.